Sr. Scientist DMPK

Employment Type

: Full-Time


: Miscellaneous

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Sr. Scientist DMPK in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Futureto people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

Position Summary:

We are seeking a highly motivated and well accomplished scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) Department of Takeda Pharmaceuticals in Cambridge, MA. This scientist will sit on multi-functional project teams to provide DMPK support to the discovery and development of small molecules, biologics, gene therapy programs with focuses on rare disease therapeutics. The support includes engaging with colleagues across Rare Disease R&D to ensure rapid and thorough translation from pre-clinical studies to clinical studies and supplying dose predictions of efficacy and safety in patients. Experience in rare disease or gene therapy is desirable. Knowledge and expertise in modeling such as PBPK and PK/PD are desirable plus.

Duties and Responsibilities:

  • Represent DMPK in discovery and development project teams.  Coordinate all DMPK related assays, and initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build thorough knowledge of biologics properties
  • Develop strategies to support both discovery and development projects and ensure effective achievement of DMPK objectives.
  • Be responsible for the design and interpretation of DMPK studies necessary for the selection of clinical candidates and for the regulatory document filing such as IND, IMPD, NDA, MAA, BLA etc. 
  • Coordinate and communicate all DMPK related activities with team leader, other function’s team leads and DMPK scientists.
  • Play a visible role in global DMPK to share learning and enhance consistency in best practices across sites and disease areas about PBPK and PKPD modeling of different modalities.
  • Keep up to date with emerging literature and science in the gene and biologics therapies

Job Qualifications:

  • Ph.D. degree in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology or related discipline;
  •  5+ year industrial experience with demonstrated impact on drug discovery and/or development and people management skills.  Less experience will be fine with appropriated title offered.
  • Thorough understanding of the basic principles of pharmacokinetics preferred.
  • Track record of scientific accomplishment as evidenced by quality and quantity of publications and/or inventions
  • Excellent written and oral communication skills to effectively communicate complex research findings and recommendations and seek to excel in a multi-disciplinary team environment.
  • Ability for critical thinking and strong analytical skills to evaluate complex information for the identification of key scientific findings related to projects. 
  • Ability to prioritize and manage multiple projects and activities while meeting tight deadlines
  • Maintains excellent working relationships with colleagues and collaborators


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

    Empowering Our People to Shine

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    No Phone Calls or Recruiters Please.



Boston, MA

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Time Type

Full time

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