Principal Scientist, Structure-Based Antibody Modeling
130 E Washington St
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Role Summary We are seeking a protein structure modeling expert to design industry-leading biotherapeutics as part of Pfizer's BioMedicine Design team in Cambridge, MA. The successful candidate will join project teams in multiple therapeutic areas to optimize protein-based therapeutic leads in early through late discovery, primarily using protein structure and molecular simulation. The candidate will also evaluate and create improved computational workflows. Other areas of opportunity may include data analysis data across programs to develop predictive models for pharmaceutical properties, and engineering improved protein scaffolds.
Works with project teams as a primary source of knowledge for structure-based computational analysis of protein biotherapeutic leads and provides optimized designs. Effectively communicates results and recommendations to colleagues with diverse scientific backgrounds. Evaluates/implements new or improved methods to increase throughput and/or accuracy of molecular modeling workflows. Analyzes data sets to discover relationships between protein structure and key pharmaceutical properties. Engineers improved general scaffolds for protein therapeutics.
PhD in biochemistry, chemistry, or a related field and 0-5 years of experience in the biopharmaceutical industry
Use of molecular structure analysis to engineer binding between proteins and their binding partners.
Expertise in one or more commonly used molecular modeling software packages.
Programming in a Linux environment using a scripting language such as Perl or Python.
PREFERRED QUALIFICATIONS Working knowledge of antibody structure and function is a significant advantage. Working knowledge of bioinformatics tools and databases. Conducting research projects in a team setting, presenting results to scientists of varying technical backgrounds. Experience optimizing physical properties of proteins. Linux systems administration skills and knowledge of HPC environments. Experience with one or more of the following software suites: Schrodinger, Rosetta, Discovery Studio, FoldX. Experience integrating multiple scientific software toolkits to develop new analysis workflows usable by colleagues. Strong track record of publication in topics involving protein structure analysis.
EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Eligible for Relocation Package Eligible for Employee Referral Bonus
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.