Res Post Doc Fellow - understanding the components of the blood coagulation system
Philadelphia, PA, US, 19104
Req ID: 23623
Employment Status: AF - Active - Regular - Full Time
The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, or MD-PhD and will, under the direction/guidance of a mentor (Rodney M. Camire, PhD. or Dr. Lindsey A. George, M.D.) assume responsibility for a specific, on-going research project. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
SPECIFIC LAB INFORMATION:
Postdoctoral fellow positions are available at The Children's Hospital of Philadelphia (CHOP) Research Institute, an interdisciplinary institution dedicated to conducting basic, clinical and translational research on conditions and diseases that affect children.
Dr. Camire and George's laboratories are interested in understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. We are also interested in translating basic biochemistry and molecular biology to develop therapeutic approaches to mitigate these events which are major causes of morbidity and mortality worldwide. Specifically, interests include new therapies for hemophilia (ex: adeno-associated virus gene therapy or protein based therapeutics) and understanding the mechanism of inhibitor formation in hemophilia.
A variety of enzymatic, biochemical, and molecular biological techniques are used in the laboratory in order to carry out our specific goals. For example, the following techniques are routinely preformed in the laboratory: modern molecular methods (site-directed mutagenesis, cloning, etc.), tissue culture (including induced pluripotent stem cells), protein purification, HPLC, FPLC, SDS-PAGE, ELISA, enzymatic kinetic assays, fluorescence spectroscopy, fluorescence anisotropy measurements, etc. Experience with murine models is also desirable.
* Conduct independent scholarly research and develop new methods and protocols
* Participate in project planning, recording and evaluation of data
* Acquire technical, lab management and grant writing skills
* Participate in seminars, lectures, poster sessions and presentation at national meetings
* Supervise junior lab members
* Assist with other research projects
Required Education and Experience
* A terminal degree PhD, MD, DVM, etc.
* According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).
Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
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