Employment Status: AF - Active - Regular - Full Time
The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, DVM, etc. and will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project. The position is in the laboratory of Dr. Stella Chou, a Principal Investigator in the Hematology Research Division. Her research focuses on pediatric blood diseases, mechanisms of normal and pathologic hematopoietic development, and the use of pluripotent stem cells to model and create tools to improve diagnosis and management of blood disorders.
The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.
Research foci include:
Understanding how transcription factor GATA1 controls normal erythro-megakaryocytic development and how GATA1 mutations cooperate with genes on chromosome 21 to cause transient myeloproliferative disease and acute megakaryocytic leukemia in patients with Down syndrome.
Disruption of candidate chromosome 21 genes using CRISPR/Cas9 technology in pluripotent stem cells to examine their role in the blood abnormalities and predisposition to leukemia associated with Down syndrome.
Creation of customized pluripotent stem cells with rare blood cell phenotypes to generate red cell reagents that would improve antibody identification in transfused patients with sickle cell disease.
Adaption of next generation sequencing technology to improve red cell matching and prevent alloimmunization in patients with sickle cell disease.
The Chou laboratory is looking for candidates with a general molecular biology background and tissue culture experience. A background in hematopoiesis and/or experience with CRISPR technology or human primary, ESC, or iPSC culture would be a plus
* Conduct independent scholarly research and develop new methods and protocols
* Participate in project planning, recording and evaluation of data
* Acquire technical, lab management and grant writing skills
* Participate in seminars, lectures, poster sessions and presentation at national meetings
* Supervise junior lab members
* Assist with other research projects
Required Licenses, Certifications, Registrations
Required Education and Experience
* A terminal degree PhD, MD, DVM, etc.
* According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Preferred Education, Experience & Cert/Lic
All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
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Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
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